Department of Medical Toxicology

Research

Recent Peer-Reviewed Publications (Previous 5 Years)

2017

  1. Kang AM and Brooks DE. Geographic distribution of scorpion exposures in the United States, 2010-2015. Am J Public Health. 2017; 107(12):e1-e6. Doi: 10.2105/AJPH.2017.304094.
  2. Heise CW, Ruha AM, Padilla-Jones A, et al. Clinical predictors of tissue necrosis following rattlesnake envenomation. Clin Toxicol (Phila). 2017;1-4. doi:10.1080/15563650.2017.1371311. [Epub ahead of print]
  3. Farrugia LA, Rhyee SH, Calello DP, et al. The Toxicology Investigators Consortium Case Registry-the 2016 Experience. J Med Toxicol. 2017; 13:203-26. doi: 10.1007/s13181-017-0627-3.
  4. O'Connor AD, Padilla-Jones A, Ruha MR. Severe bark scorpion envenomation in adults. Clin Toxicol (Phila). 2017 Jul 28:1-5. doi: 10.1080/15563650.2017.1353095. [Epub ahead of print]
  5. Spyres MB, Ruha AM, Kleinschmidt K, Vohra R, Smith E, Padilla-Jones A. Epidemiology and clinical outcomes of snakebite in the elderly: a ToxIC database study. Clin Toxicol (Phila). 2017 Jul 13:1-5. doi: 10.1080/15563650.2017.1342829. [Epub ahead of print]
  6. Raschke RA, Gallo T, Curry SC, et al. Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia. J Thromb Haemost. 2017; 15(8):1640-5. doi: 10.1111/jth.13758
  7. Heise CW, Malashock H, Brooks DE. A review of vilazodone exposures with focus on serotonin syndrome effects. Clin Toxicol (Phila). 2017:1. doi: 10.1080/15563650.2017.1332369.
  8. Kang AM and Brooks DE. Nationwide scorpion exposures reported to US poison control centers from 2005 to 2015. J Med Toxicol. 2017; 13(2):158-65. Doi: 10.1007/s13181-016-0594-0.
  9. Coorg V, Levitan RD, Gerkin RD, et al. Clinical Presentation and Outcomes Associated with Different Treatment Modalities for Pediatric Bark Scorpion Envenomation. J Med Toxicol. 2017; 13(1):66-70. doi:10.1007/s13181-016-0575-3.
  10. Weemhoff JL, Woolbright BL, Jenkins RE, et al. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int. 2017; 37:377-384. doi:10.1111/liv.13202.

2016

  1. Spyres MB, Ruha AM, Seifert S, et al (2016). Occupational Snake Bites: a Prospective Case Series of Patients Reported to the ToxIC North American Snakebite Registry. J Med Toxicol. Dec;12(4):365-369.
  2. Heise CW and Brooks DE (2016). Ayahuasca Exposure: Descriptive Analysis of Calls to US Poison Control Centers from 2005 to 2015. J Med Toxicol. 1-4. doi:10.1007/s13181-016-0593-1.
  3. Mowry JB, Spyker DA, Brooks DE et al. Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 33rd Annual Report. Clin Toxicol (Phila). 2016 Dec;54(10):924-1109
  4. Lasoff DR, Ruha AM, Curry SC, Koh C, Clark RF (2016). A new F(ab')(2) antivenom for the treatment of crotaline envenomation in children. Am J Emerg Med. Oct;34(10):2003-2006. doi: 10.1016/j.ajem.2016.07.061.
  5. Heise CW, Skolnik AB, Raschke RA, et al. Two Cases of Refractory Cardiogenic Shock Secondary to Bupropion Successfully Treated with Veno-Arterial Extracorporeal Membrane Oxygenation. J Med Toxicol. 2016 Sep;12(3):301-4. doi: 10.1007/s13181-016-0539-7.
  6. Farrugia LA, Rhyee SH, Campleman SL, et al (2016). The Toxicology Investigators Consortium Case Registry-the 2015 Experience. J Med Toxicol. Sep;12(3):224-47. doi: 10.1007/s13181-016-0580-6.
  7. Thomas KC, Wilkins DG, Curry SC, et al. Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose. J Forensic Sci. 2016;61:1301-6. doi:10.1111/1556-4029.13169.
  8. Levine M, O'Connor AD, Padilla-Jones A and Gerkin RD. Comparison of prothrombin time and aspartate aminotransferase in predicting hepatotoxicity after acetaminophen overdose. J Med Toxicol. 2016;12:100-6. doi:10.1007/s13181-015-0504-x.
  9. Spyres MB, Oakley E, Graeme KA. Ultrasound to evaluate effectiveness of hyperbaric oxygen therapy. Intern Emerg Med. 2016 Jul 28.
  10. Kang AM and Brooks DE. US poison control center calls for infants 6 months of age and younger. Pediatrics. 2016; 137(2): e20151865. Doi: 10.1542/peds.2015-1865.

2015

  1. Otaluka O, Corrado R, Brooks DE, Nelson DB (2015). A survey of poison center knowledge and utilization among urban and rural residents in Arizona. Toxicology Reports. 2:203-204.
  2. Bosak A, Brooks DE, Welch S, Padilla-Jones A, Gerkin RD (2015). A retrospective review of 911 calls to a regional poison control center. Journal of Family Medicine and Primary Care. 4(4):546-550.
  3. Mowry JB, Spyker DA, Brooks DE, McMillan N, Schauben JL (2015). 2014 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 32nd annual report. Clin Toxicol (Phila). 53(10):962-1147.
  4. Wong A, Vohra R, Ruha AM, et al (2015). The Global Educational Toxicology Uniting Project (GETUP): an Analysis of the First Year of a Novel Toxicology Education Project. J Med Toxicol. Sep;11(3):295-300. doi: 10.1007/s13181-015-0479-7.
  5. Curry SC, Padilla-Jones A, O'Connor AD, et al. Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. J Med Toxicol. 2015 Jun;11(2):169-78. doi: 10.1007/s13181-014-0431-2.
  6. LoVecchio F and Heise CW (2015). Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience. Am J Emerg Med. Jun;33(6):844-5. doi: 10.1016/j.ajem.2015.03.030.
  7. LoVecchio F and Zoph O (2015). Incidence of electronic cigarette exposures in children skyrockets in Arizona. Am J Emerg Med. Jun;33(6):834-5. doi: 10.1016/j.ajem.2015.02.036.
  8. Cook SF, King AD, Chang Y, et al. Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: clinical and animal model applications. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:131-41. doi: 10.1016/j.jchromb.2015.01.028.
  9. Heise CW, Beutler D, Bosak A, et al. Massive Atenolol, Lisinopril, and Chlorthalidone Overdose Treated with Endoscopic Decontamination,Hemodialysis, Impella Percutaneous Left Ventricular Assist Device, and ECMO. J Med Toxicol. 2015 Mar;11(1):110-4. doi: 10.1007/s13181-014-0419-y.
  10. Curry SC, Brooks DE, Skolnik AB, et al. Effect of a medical toxicology admitting service on length of stay, cost, and mortality among inpatients discharged with poisoning-related diagnoses. J Med Toxicol. 2015 Mar;11(1):65-72. doi: 10.1007/s13181-014-0418-z.
  11. French R, Brooks DE, Ruha AM, et al (2015). Gila monster (Heloderma suspectum) envenomation: Descriptive analysis of calls to United States Poison Centers with focus on Arizona cases. Clin Toxicol (Phila). Jan;53(1):60-70. doi: 10.3109/15563650.2014.988791

2014

  1. Woolbright BL, McGill MR, Staggs VS, et al. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicol Sci. 2014 Dec;142(2):436-44. doi: 10.1093/toxsci/kfu195.
  2. Thomas KC, Wilkins DG, Curry SC, et al. Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose. J Forensic Sci. 2016 Sep;61(5):1301-6. doi: 10.1111/1556-4029.13169.
  3. Bosak AR, Graeme KA, Evans MD. Hemodialysis treatment of monomorphic ventricular tachycardia associated with chronic lithium toxicity. J Med Toxicol. 2014 Sep;10(3):303-6. doi: 10.1007/s13181-013-0366-z.
  4. Ward J, Kanchagar C, Veksler-Lublinsky I, et al. Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12169-74. doi: 10.1073/pnas.1412608111.
  5. Weemhoff JL, Woolbright BL, Jenkins RE, et al. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int. 2016 Jul 18. doi: 10.1111/liv.13202.
  6. Bosak AR, Ruha AM, Graeme KA. A case of neurotoxicity following envenomation by the Sidewinder rattlesnake, Crotalus cerastes. J Med Toxicol. 2014 Jun;10(2):229-31. doi: 10.1007/s13181-013-0373-0.
  7. Graeme KA. Mycetism: a review of the recent literature. J Med Toxicol. 2014 Jun;10(2):173-89. doi: 10.1007/s13181-013-0355-2.
  8. Levine M, Pizon AF, Padilla-Jones A, Ruha AM (2014). Warfarin overdose: a 25-year experience. J Med Toxicol. 2014 Jun;10(2):156-64. doi: 10.1007/s13181-013-0378-8.
  9. McGill MR, Cao M, Svetlov A, et al. Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers. 2014 May;19(3):222-30. doi: 10.3109/1354750X.2014.897757.
  10. Levine M, Ruha AM, Padilla-Jones A, et al (2014). Bleeding following rattlesnake envenomation in patients with preenvenomation use of antiplatelet or anticoagulant medications. Acad Emerg Med. Mar;21(3):301-7. doi: 10.1111/acem.12333.
  11. Levine M, Skolnik AB, Ruha AM, et al (2014). Complications following antidotal use of intravenous lipid emulsion therapy. J Med Toxicol. Mar;10(1):10-4. doi: 10.1007/s13181-013-0356-1.
  12. Kopec KT, Brent J, Banner W, et al (2014). Management of cardiac dysrhythmias following hydrocarbon abuse: clinical toxicology teaching case from NACCT acute and intensive care symposium. Clin Toxicol (Phila). Feb;52(2):141-5. doi: 10.3109/15563650.2014.882001.
  13. McGill MR, Li F, Sharpe MR, et al. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014 Feb;88(2):391-401. doi: 10.1007/s00204-013-1118-1.
  14. Ruha AM and Levine M (2014). Central nervous system toxicity. Emerg Med Clin North Am. Feb;32(1):205-21. doi: 10.1016/j.emc.2013.09.004.

2013

  1. Boyer L, Degan J, Ruha AM, et al (2013). Safety of intravenous equine F(ab')2: insights following clinical trials involving 1534 recipients of scorpion antivenom. Toxicon. Dec 15;76:386-93. doi: 10.1016/j.toxicon.2013.07.017.
  2. Ruha AM. Recommendations for provoked challenge urine testing (2013). J Med Toxicol. Dec;9(4):318-25. doi: 10.1007/s13181-013-0350-7.
  3. Raschke RA, Curry SC, Warkentin TE, Gerkin RD. Improving clinical interpretation of the anti-platelet factor 4/heparin enzyme-linked immunosorbent assay for the diagnosis of heparin-induced thrombocytopenia through the use of receiver operating characteristic analysis, stratum-specific likelihood ratios, and Bayes theorem. Chest. 2013 Oct;144(4):1269-75. doi: 10.1378/chest.12-2712.
  4. Glogan D, Levitan RD, Brooks DE, Gerkin RD (2013). Unintentional use of mistaken insulin products: a retrospective review of poison center data. Journal of Emergency Medicine. 45(4):547-553.
  5. Levine M, Curry SC, Padilla-Jones A, Ruha AM. Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center. Ann Emerg Med. 2013 Sep;62(3):252-8. doi: 10.1016/j.annemergmed.2013.03.018.
  6. Bosak A, LoVecchio F, Levine M (2013). Recurrent seizures and serotonin syndrome following "2C-I" ingestion. J Med Toxicol. Jun;9(2):196-8. doi: 10.1007/s13181-013-0287-x.
  7. Levine M, Froberg B, Ruha AM, et al (2013). Assessing the toxicity and associated costs among pediatric patients admitted with unintentional poisonings of attention-deficit/hyperactivity disorder drugs in the United States. Clin Toxicol (Phila). Mar;51(3):147-50. doi: 10.3109/15563650.2013.772623.
  8. Levine M, Mihalic J, Ruha AM, et al (2013). Heavy metal contaminants in yerberia shop products. J Med Toxicol. Mar;9(1):21-4. doi: 10.1007/s13181-012-0231-5.
  9. Cohen JP, Ruha AM, Curry SC, et al (2013). Plasma and urine dimercaptopropanesulfonate concentrations after dermal application of transdermal DMPS (TD-DMPS). J Med Toxicol. Mar;9(1):9-15. doi: 10.1007/s13181-012-0272-9.
  10. Levine M, O’Connor AD, Tasset M (2013). Methemoglobinemia after a mediastinal stab wound. J Emerg Med. 45(5): 153-156.

2012

  1. Austin T, Brooks DE, Welch S, LoVecchio F (2012). A survey of primary care office: triage of poisoning calls without a poison control center. International J of Family Medicine. Doi:10.1155/2012/417823.
  2. O'Connor AD and Ruha MR (2012). Clinical Course of Bark Scorpion Envenomation Managed Without Antivenom. J Med Toxicol. 8(3): 258-62.
  3. Levine M, LoVecchio F, Ruha AM, et al (2012). Influence of drug use on morbidity and mortality in heatstroke. J Med Toxicol. 2012 Sep;8(3):252-7. doi: 10.1007/s13181-012-0222-6.
  4. Levine M, Ruha AM (2012). Overdose of atypical antipsychotics: clinical presentation, mechanisms of toxicity and management. CNS Drugs. Jul 1;26(7):601-11. doi: 10.2165/11631640-000000000-00000.
  5. Levine M, Curry SC, Ruha AM, et al (2012). Ethylene glycol elimination kinetics and outcomes in patients managed without hemodialysis. Ann Emerg Med. Jun;59(6):527-31. doi: 10.1016/j.annemergmed.2011.12.001.
  6. Levine M, Ruha AM, Goldstein JN (2012). Can asymptomatic patients with a supratherapeutic international normalized ratio be safely treated as outpatients? Ann Emerg Med. Apr;59(4):318-20. doi: 10.1016/j.annemergmed.2011.04.023.
  7. McGill MR, Sharpe MR, Williams CD, et al. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 2012 Apr;122(4):1574-83. doi: 10.1172/JCI59755.
  8. Truitt C, Brooks DE, et al (2012). Retrospective review of poison center data involving unintentional supratherapeutic ingestions of beta-blocker and/or calcium blocker medications. J Med Toxicol. 8(2):135-139.
  9. Levine M, Brooks DE, Franken A, Graham R (2012). Delayed-onset seizure and cardiac arrest after amitriptyline overdose treated with intravenous lipid emulsion therapy. Pediatrics. 130(2):e432-38.
  10. Levine M and O'Connor AD (2012). Obstetric toxicology: teratogens. Emerg Med Clin North Am. 30(4): 977-90.